L-serine is the amino acid core component (about 15% proportion) of the natural moisturizing factor NMFs in the stratum corneum of the skin. It can repair the skin barrier, accelerate the renewal and brightening of the stratum corneum, prevent and treat the skin inflammatory response (IL-8) caused by the overexpression of PAR2 receptors, and improve discomforts such as itching, redness and dryness during the pathological period of the skin;